phenobarbital raises toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers may improve the metabolism of ifosfamide to its Lively alkylating metabolites.Through pregnancy, this medication needs to be utilised only when Obviously desired. It may harm an unborn toddler. Newborn infants o